Table 1. Correlation of Progressive
Deterioration of Cerebral Blood Flow and Tissue Oxygenation With Resultant
Effects on Brain
CBF
(mL/100 g/min) |
Effect on Central Nervous System |
PO2 (mm Hg) |
| 50 |
Normal |
100 |
| 30-40 |
Depression of electroencephalogram |
|
| 20-30 |
Anaerobic metabolism |
40 |
| 15-20 |
Adenosine triphosphate depletion, coma |
25 |
| 8-10 |
Viability threshold
K+
leak
Membrane depolarization |
12 |
| Trickle |
Continued electrolyte flux
Continued anaerobic metabolism/lactate production
Worsened acidosis |
|
| 0 |
Metabolism ceases
Electrolyte flux ceases |
|
CBF indicates cerebral blood flow.